Research Publications
Explore our comprehensive collection of peer-reviewed research articles across multiple scientific disciplines
49
Articles in Category
2007-2025
Publication Years
Ophthalmology
BOSS® EYEPublications describe research using the FDA-cleared BOSS® Ophthalmology system for imaging and elastic property measurement of ocular structures. The device is not cleared or validated for diagnostic use.
2020
Ambekar YS; Singh M; Scarcelli G; …;
Characterization of retinal biomechanical properties using Brillouin microscopy
J Biomed Opt
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2020
Ambekar YS; Singh M; Zhang J; …;
Multimodal quantitative optical elastography of the crystalline lens
Biomed Opt Express
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2017
Ambrósio R Jr; Correia FF; Lopes B; …;
Corneal Biomechanics in Ectatic Diseases: Refractive Surgery Implications
Open Ophthalmol J
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2016
Besner S; Scarcelli G; Pineda R; …;
In Vivo Brillouin Analysis of the Aging Crystalline Lens
Invest Ophthalmol Vis Sci
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2024
Cao J; Yu Y; Ma Y; …;
Evaluation of Corneal Biomechanics Using Brillouin Microscopy in Chinese Adults With Myopia
J Refract Surg
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2025
Chang L; Song F; Qu S; …;
In vivo Brillouin analysis of lens nucleus and cortex in adult myopic eyes and their correlation with accommodation
Invest Ophthalmol Vis Sci
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2013
Cherfan D; Verter EE; Melki S; …;
Collagen Cross-Linking Using Rose Bengal and Green Light Increases Corneal Stiffness
Invest Ophthalmol Vis Sci
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2023
Elhusseiny AM; Scarcelli G; Saeedi OJ;
Corneal Biomechanical Measures for Glaucoma: A Clinical Approach
Bioengineering (Basel)
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2020
Eltony AM; Clouser F; Shao P; …;
Brillouin Microscopy Visualizes Centralized Corneal Edema in FECD
Cornea
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2022
Eltony AM; Clouser F; Shao P; …;
Measuring mechanical anisotropy of the cornea with high sensitivity using Brillouin microscopy
Nat Commun
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2023
Esporcatte LPG; Salomão MQ; Lopes BT; …;
Biomechanics in keratoconus diagnosis
Curr Eye Res
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2025
Hammoud B; Zhang H; Susanna BN; …;
Focal Weakening/Thinnest Corneal Point Proximity is Associated with Ectasia Susceptibility after LASIK
Ophthalmol Sci
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2017
Hillen M
The Hubble telescope of the eye
The Ophthalmologist
Link not available
2025
Jiang Q; Sun Y; Gu Z; …;
Application of the Brillouin Optical Scanning System in the Regional Corneal Biomechanical Evaluation of Keratoconus and Its Correlation with Corvis ST Parameters
Bioengineering (Basel)
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2023
Lopes BT; Elsheikh A
In Vivo Corneal Stiffness Mapping by the Stress-Strain Index Maps and Brillouin Microscopy
Curr Eye Res
Link not available
2024
Ma Y; Cao J; Yu Y; …;
Brillouin assessment of the crystalline lens in patients with high myopia after ICL V4c
Acta Ophthalmol
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2024
Ma Y; Cao J; Yu Y; …;
A Brillouin microscopy analysis of the crystalline lenses of Chinese adults with myopia
Graefes Arch Clin Exp Ophthalmol
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2022
Nair A; Ambekar YS; Zevallos-Delgado C; …;
Multiple Optical Elastography Techniques Reveal the Regulation of Corneal Stiffness by Collagen XII
Invest Ophthalmol Vis Sci
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2017
Randleman JB; Su JP; Scarcelli G;
Biomechanical Changes After LASIK Flap Creation Combined With Rapid CXL Measured With Brillouin Microscopy
J Refract Surg
Link not available
2024
Randleman JB; Zhang H; Asroui L; …;
Subclinical Keratoconus Detection Using Motion-Tracking Brillouin Microscopy
Ophthalmology
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2025
Randleman JB; Zhang H; Hammoud B; …;
Three-Dimensional Mechanical Characterization of Normal, Subclinical, and Keratoconic Corneas via Brillouin Microscopy
Am J Ophthalmol
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2020
Sánchez-Iranzo H; Bevilacqua C; Diz-Muñoz A; …;
A 3D Brillouin microscopy dataset of the in-vivo zebrafish eye
Data Brief
Link not available
2014
Scarcelli G; Besner S; Pineda R; …;
Biomechanical characterization of keratoconus corneas ex vivo using Brillouin microscopy
Invest Ophthalmol Vis Sci
Link not available
2011
Scarcelli G; Kim P; Yun SH
In vivo measurement of age-related stiffening in the crystalline lens using Brillouin scattering
Biophys J
Link not available
2013
Scarcelli G; Kling S; Quijano E; …;
Brillouin microscopy of collagen crosslinking in corneas
Invest Ophthalmol Vis Sci
Link not available
2012
Scarcelli G; Pineda R; Yun SH
Brillouin optical microscopy for corneal biomechanics
Invest Ophthalmol Vis Sci
Link not available
2007
Scarcelli G; Yun SH
Confocal Brillouin microscopy for 3D mechanical imaging
Nat Photonics
Link not available
2012
Scarcelli G; Yun SH
In vivo Brillouin optical microscopy of the human eye
Opt Express
Link not available
2024
Schumacher J; Lopez RR; Larin K; …;
Functional effects of spatial-varying lens mechanical properties in accommodation
JPhys Photonics
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2019
Seiler TG; Shao P; Eltony A; …;
Brillouin Spectroscopy of Normal and Keratoconus Corneas
Am J Ophthalmol
Link not available
2018
Seiler TG; Shao P; Frueh BE; …;
The influence of hydration on different mechanical moduli of the cornea
Graefes Arch Clin Exp Ophthalmol
Link not available
2016
Shao P; Besner S; Zhang J; …;
Etalon filters for Brillouin microscopy of highly scattering tissues
Opt Express
Link not available
2019
Shao P; Eltony AM; Seiler TG; …;
Spatially-resolved Brillouin spectroscopy reveals biomechanical abnormalities in keratoconus in vivo
Sci Rep
Link not available
2025
Song F; Chang L; Qu S; …;
In vivo analysis of age-related changes in longitudinal modulus and morphology of the crystalline lens: A combined Brillouin optical scanning and OCT study
Exp Eye Res
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2025
Song F; Wang Y; Chang L; …;
[Application of the Brillouin optical scanning system to investigate the biomechanical properties of the myopic lens and their changes before and after cycloplegia]
Zhonghua Yan Ke Za Zhi
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2025
Vinciguerra R; Herber R; Cen KZ; …;
KERATO Biomechanics Study 2: Before and After CXL Using Brillouin Microscopy and Dynamic Scheimpflug Imaging
J Refract Surg
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2024
Vinciguerra R; Palladino S; Herber R; …;
The KERATO Biomechanics Study 1: Brillouin Microscopy vs Dynamic Scheimpflug Imaging
J Refract Surg
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2020
Wang K; Venetsanos DT; Hoshino M; …;
A Modeling Approach for Investigating Opto-Mechanical Relationships in the Human Eye Lens
IEEE Trans Biomed Eng
Link not available
2019
Webb JN; Langille E; Hafezi F; …;
Biomechanical Impact of Localized CXL Beyond the Irradiated Area
J Refract Surg
Link not available
2017
Webb JN; Su JP; Scarcelli G
Mechanical outcome of accelerated CXL evaluated by Brillouin microscopy
J Cataract Refract Surg
Link not available
2020
Webb JN; Zhang H; Sinha Roy A; …;
Detecting Mechanical Anisotropy of the Cornea Using Brillouin Microscopy
Transl Vis Sci Technol
Link not available
2017
Weber IP; Yun SH; Scarcelli G; …;
Role of cell body density in ruminant retina mechanics
Phys Biol
Link not available
2025
Yu Y; Cao J; Ma Y; …;
Comparison of corneal biomechanics in post-SMILE, post-LASEK, and normal eyes with Brillouin microscopy
J Optom
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2018
Yun SH; Chernyak D
Brillouin microscopy: assessing ocular tissue biomechanics
Curr Opin Ophthalmol
Link not available
2022
Zhang H; Asroui L; Randleman JB; …;
Motion-tracking Brillouin microscopy for in-vivo corneal biomechanics mapping
Biomed Opt Express
Link not available
2023
Zhang H; Asroui L; Tarib I; …;
Motion-tracking Brillouin microscopy evaluation of normal, keratoconic, and post-LVC corneas
Am J Ophthalmol
Link not available
2019
Zhang H; Roozbahani M; Piccinini AL; …;
Depth-Dependent Reduction of Biomechanical Efficacy of Contact Lens-Assisted CXL
J Refract Surg
Link not available
2020
Zhang H; Roozbahani M; Piccinini AL; …;
Brillouin depth-dependent analysis of CXL performed over/under the LASIK flap
J Cataract Refract Surg
Link not available
Review
2025
Cao J; Yu Y; Ma Y; …;
Brillouin Microscopy: An Emerging Tool for Biomechanical Analysis in Ophthalmology
J Refract Surg
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Life Sciences
BOSS® LSThe publications below describe exploratory or preclinical research using prototype versions of the BOSS® Life Science platform. The studies were performed for research purposes only and do not imply regulatory clearance or clinical validation. BOSS® Life Science is not cleared or approved by the FDA or other regulatory authorities and is not for clinical or diagnostic use.
2024
Ambekar YS; Caiaffa CD; Wlodarczyk BJ; …;
Optical coherence tomography–guided Brillouin microscopy highlights regional tissue stiffness during anterior neural tube closure in the Mthfd1l murine mutant
Development 151(10):dev202475
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2024
Caiaffa CD; Tukeman G; Delgado CZ; …;
Dolutegravir induces FOLR1 expression during brain organoid development
Front Mol Neurosci 17:1394058
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2022
Conrad C; Moore K; Polacheck W; …;
Mechanical Modulation of Ovarian Cancer Tumor Nodules Under Flow
IEEE Trans Biomed Eng 69:294–301
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2023
Handler C; Scarcelli G; Zhang J
Time-lapse mechanical imaging of neural tube closure in live embryo using Brillouin microscopy
Sci Rep 13:1161
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2024
Hutchins R; Schumacher J; Frank E; …;
Brillouin spectroscopy via an atomic line monochromator
Opt Express 32(11):18572–18584
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2024
Mekonnen TT; Ambekar YS; Zevallos-Delgado C; …;
Dual optical elastography detects TGF-β–induced alterations in the biomechanical properties of skin scaffolds
J Biomed Opt 29(9):095002
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2022
Nikolić M; Scarcelli G; Tanner K
Multimodal microscale mechanical mapping of cancer cells in complex microenvironments
Biophys J 121(19):3586–3599
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2021
Roberts AB; Zhang J; Raj Singh V; …;
Tumor cell nuclei soften during transendothelial migration
J Biomech 121:110400
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2024
Rodríguez-López R; Wang Z; Oda H; …;
Network Viscoelasticity from Brillouin Spectroscopy
Biomacromolecules 25(2):740–750
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2015
Scarcelli G; Polacheck WJ; Nia HT; …;
Noncontact 3D mapping of intracellular hydromechanical properties by Brillouin microscopy
Nat Methods 12:1132–1134
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2024
So WY; Johnson B; Gordon PB; …;
Macrophage-mediated mesoscale brain mechanical homeostasis mechanically imaged via optical tweezers and Brillouin microscopy in vivo
Mol Biol Cell 35(1)
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2020
Zhang J; Alisafaei F; Nikolić M; …;
Nuclear Mechanics within Intact Cells Is Regulated by Cytoskeletal Network and Internal Nanostructures
Small 16(51):1907688
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2017
Zhang J; Nou XA; Kim H; …;
Brillouin flow cytometry for label-free mechanical phenotyping of the nucleus
Lab Chip 17(4):663–670
View Article
2021
Zhang J; Scarcelli G
Mapping mechanical properties of biological materials via an add-on Brillouin module to confocal microscopes
Nat Protoc 16:1251–1275
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IVF / Reproductive Biology
BOSS® IVFThe following publications describe independent or collaborative research using developmental or prototype versions of the BOSS® IVF technology. These studies are exploratory and do not represent established clinical performance. BOSS® IVF is an investigational research device, not cleared or approved by the FDA or other regulatory authorities, and not available for clinical or diagnostic use.
2023
Bevilacqua C; Gomez JM; Fiuza UM; …;
High-resolution line-scan Brillouin microscopy for live imaging of mechanical properties during embryo development
Nat Methods 20:1110–1119
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BOSS®
2024
Caiaffa CD; Ambekar YS; Singh M; …;
Disruption of Fuz in mouse embryos generates hypoplastic hindbrain development and reduced cranial nerve ganglia
Dev Dyn 253(9):846–858
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2021
Chan CJ; Bevilacqua C; Prevedel R
Mechanical mapping of mammalian follicle development using Brillouin microscopy
Commun Biol 4:1116
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BOSS®
2025
Kim K; Kim E; Barnes CS; …;
Exploration of oocyte and embryo development via biomechanics using Brillouin microscopy
(In press)
In press
2018
Schlüßler R; Möllmert S; Abuhattum S; …;
Mechanical Mapping of Spinal Cord Growth and Repair in Living Zebrafish Larvae by Brillouin Imaging
Biophys J 115(5):911–923
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2023
Shi C; Handler C; Florn H; …;
Monitoring Mechanical Evolution During Neural Tube Closure of Chick Embryo
J Vis Exp (201):e66117
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BOSS®
2024
Taft R; Prentiss S; Glucksman HP; …;
Use of Brillouin spectroscopy as a non-contact, non-destructive method to detect biomechanical changes in mouse oocytes during fertilization
Fertil Steril (Suppl.)
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