A New Dimension in Cellular and Tissue Analysis
Cells and tissues are shaped not only by genetics and biochemistry, but also by biomechanics — their stiffness, elasticity, and viscosity. Until now, most biomechanical methods (AFM, indenters, tweezers) have been invasive, slow, or difficult to integrate into live-cell workflows.
BOSS® LS brings biomechanics into focus with the world’s first Brillouin-based scanning microscope available for laboratory use. Built on Intelon Optics’s decade of innovation and experience developing advanced optical technologies for the clinic and the lab, BOSS® LS makes non-contact, high-resolution biomechanics mapping a practical tool for modern research.
Label-free and non-contact due to optical scanning.
Automated 3D scanning.
Sub-micron spatial resolution
Direct assessment of biomechanics (stiffness and viscosity)
Flexible configurations – Choose a complete standalone system (shown in the right image) or a custom add-on module for most major inverted microscopes.
BOSS® Life Science combines the advantages of force-based methods (AFM, indentation, tweezers) with the imaging power of advanced microscopy (confocal, multiphoton, light-sheet). With its ability to map biomechanics in living systems, BOSS® Life Science opens new research opportunities across disciplines:
Cellular biomechanics & mechanobiology
Cancer cell biology & tumor microenvironment
Stem cell research & regenerative medicine
Drug discovery & toxicology
In-vitro fertilization & developmental biology
The scan image above shows Brillouin stiffness measurements of HeLa cells in a Z plane with lateral resolution at 1 μm. In the color map, 5.01 and 5.5 GHz respectively, correspond to 2.18 and 2.62 GPa.
The Future of Research is Biomechanics
As biology moves beyond genes and molecules, mechanics is the new frontier. With BOSS® LS, you can explore this dimension with speed, safety, and precision — and join the next wave of discovery.